Fluorine in a Native Protein Environment—How the Spatial Demand and Polarity of Fluoroalkyl Groups Affect Protein Folding


  • This work was supported by the Deutsche Forschungsgemeinschaft (KO1976/2-1) and the Graduiertenkolleg (#788).


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Give and take: The influence of fluoro substitution of amino acid side chains on their interaction profile in a native polypeptide environment was studied systematically. The fluorination of alkyl groups has opposing electrostatic and steric consequences for the stability of hydrophobic protein cores.