Get access

Fluorine in a Native Protein Environment—How the Spatial Demand and Polarity of Fluoroalkyl Groups Affect Protein Folding


  • This work was supported by the Deutsche Forschungsgemeinschaft (KO1976/2-1) and the Graduiertenkolleg (#788).


original image

Give and take: The influence of fluoro substitution of amino acid side chains on their interaction profile in a native polypeptide environment was studied systematically. The fluorination of alkyl groups has opposing electrostatic and steric consequences for the stability of hydrophobic protein cores.

Get access to the full text of this article