Highly Enantioselective Conjugate Reduction of β,β-Disubstituted α,β-Unsaturated Nitriles


  • This work was supported by a Korea Research Foundation grant funded by the Korean Government (R08-2004-000-10429-0). The LC and GC equipment was supported by the Faculty Research Fund 2005, Sungkyunkwan University. Prof. C. Song and E. Kwon at SKKU are acknowledged for valuable advice and assistance with the chiral analysis.


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Easy access: The highly enantioselective conjugate reduction of α,β-unsaturated nitriles is achieved by employing bench-top stable copper(II) acetate and josiphos (L) as the ligand in the presence of polymethylhydrosiloxane (PMHS). This protocol provides ready access to valuable chiral β-aryl substituted nitriles in good yields and with excellent enantioselectivities.