This research was supported by the National Science Foundation (CHE-040638). Fellowship support from Eli Lilly and Company (M.P.C. and N.M.D.) is gratefully acknowledged.
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Communication
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Metal-Catalyzed [2+2+1] Cycloadditions of 1,3-Dienes, Allenes, and CO†
Article first published online: 9 MAR 2006
DOI: 10.1002/anie.200600300
Copyright © 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Wender, P. A., Croatt, M. P. and Deschamps, N. M. (2006), Metal-Catalyzed [2+2+1] Cycloadditions of 1,3-Dienes, Allenes, and CO. Angew. Chem. Int. Ed., 45: 2459–2462. doi: 10.1002/anie.200600300
- †
Publication History
- Issue published online: 24 MAR 2006
- Article first published online: 9 MAR 2006
- Manuscript Received: 24 JAN 2006
Keywords:
- allenes;
- cycloaddition;
- dienes;
- Pauson–Khand reaction;
- rhodium
Closing the circle: RhI-catalyzed [2+2+1] cycloadditions are achieved under mild reaction conditions and in good to excellent yields with catalyst loading as low as 0.1 mol %. The diene–allenes react selectively with the proximal double bonds of the allene and diene units, thus allowing for a variety of substitutions. DCE=1,2-dichloroethane, TFE=2,2,2-trifluoroethanol, Ts=tosyl.