A Surface-Bound DNA Switch Driven by a Chemical Oscillator


  • This work was supported by the Deutsche Forschungsgemeinschaft (Emmy Noether grant DFG SI 761/2-2). T.L. and M.O. are supported by the LMU International Graduate School “Nanobiotechnology”.


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Proton control: Chemical oscillations produced in a continuously stirred tank reactor can be used to drive the conformational changes of DNA nanoswitches immobilized on a thin gold film (see scheme). The autonomous switching events of these substrate-bound actuators are characterized in fluorescence measurements by utilizing energy transfer between the fluorophores and gold substrate.