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Keywords:

  • bioconjugation;
  • bioorganic chemistry;
  • oximes;
  • protein modifications
Thumbnail image of graphical abstract

One hit wonder: A biomimetic transamination reaction has been developed that employs pyridoxal-5-phosphate to modify the N terminus of proteins and peptides under mild conditions. This technique introduces a uniquely reactive carbonyl group in a single location (see scheme), thus allowing further elaboration through oxime or hydrazone formation. This modification strategy is also compatible with proteins containing a free cysteine residue.