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Keywords:

  • isonitriles;
  • multicomponent reaction;
  • O-iodoxybenzoic acid;
  • oxidation;
  • Passerini reaction
Thumbnail image of graphical abstract

High proof: An alcohol instead of an aldehyde is an effective reaction partner in the Passerini reaction (P-3CR) in the presence of O-iodoxybenzoic acid (IBX). Thus, by simply heating a solution of an alcohol, a carboxylic acid, an isonitrile, and IBX at 40 °C, an oxidation/P-3CR sequence occurred smoothly to afford the α-acyloxy carboxamide in good-to-excellent yield.