Financial support from the CNRS and the Institut de Chimie des Substances Naturelles is gratefully acknowledged. We thank Dr. A. Plant of (Syngenta) and Professor R.J.K. Taylor (York University, UK) for fruitful discussions.
Alcohols in Isonitrile-Based Multicomponent Reaction: Passerini Reaction of Alcohols in the Presence of O-Iodoxybenzoic Acid†
Article first published online: 25 APR 2006
Copyright © 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 45, Issue 21, pages 3495–3497, May 19, 2006
How to Cite
Ngouansavanh, T. and Zhu, J. (2006), Alcohols in Isonitrile-Based Multicomponent Reaction: Passerini Reaction of Alcohols in the Presence of O-Iodoxybenzoic Acid. Angew. Chem. Int. Ed., 45: 3495–3497. doi: 10.1002/anie.200600588
- Issue published online: 10 MAY 2006
- Article first published online: 25 APR 2006
- Manuscript Received: 14 FEB 2006
- multicomponent reaction;
- O-iodoxybenzoic acid;
- Passerini reaction
High proof: An alcohol instead of an aldehyde is an effective reaction partner in the Passerini reaction (P-3CR) in the presence of O-iodoxybenzoic acid (IBX). Thus, by simply heating a solution of an alcohol, a carboxylic acid, an isonitrile, and IBX at 40 °C, an oxidation/P-3CR sequence occurred smoothly to afford the α-acyloxy carboxamide in good-to-excellent yield.