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Keywords:

  • alkylation;
  • homogeneous catalysis;
  • iridium;
  • reduction;
  • ruthenium
Thumbnail image of graphical abstract

The compatibility between [{IrCl(cod)}2] and ruthenium complex 1 to achieve asymmetric α-alkylative reduction of prochiral ketones with primary alcohols is an essential factor in obtaining optically active alcohols with elongation of the carbon skeleton in good yields with a high enantioselectivity.