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Ir- and Ru-Catalyzed Sequential Reactions: Asymmetric α-Alkylative Reduction of Ketones with Alcohols


  • This work was supported by a Grant-in-Aid for Scientific Research for Young Scientists (A; No. 15685006) to Y.N. from the Ministry of Education, Culture, Sports, Science and Technology, Japan.


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The compatibility between [{IrCl(cod)}2] and ruthenium complex 1 to achieve asymmetric α-alkylative reduction of prochiral ketones with primary alcohols is an essential factor in obtaining optically active alcohols with elongation of the carbon skeleton in good yields with a high enantioselectivity.

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