This research was supported by the National Science Foundation (CHE-040638). Fellowship support from Eli Lilly and Company (R.S. and N.M.D.) is gratefully acknowledged.
RhI-Catalyzed CC Bond Activation: Seven-Membered Ring Synthesis by a [6+1] Carbonylative Ring-Expansion Reaction of Allenylcyclobutanes†
Article first published online: 9 MAY 2006
Copyright © 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 45, Issue 24, pages 3957–3960, June 12, 2006
How to Cite
Wender, P. A., Deschamps, N. M. and Sun, R. (2006), RhI-Catalyzed CC Bond Activation: Seven-Membered Ring Synthesis by a [6+1] Carbonylative Ring-Expansion Reaction of Allenylcyclobutanes. Angew. Chem. Int. Ed., 45: 3957–3960. doi: 10.1002/anie.200600806
- Issue published online: 1 JUN 2006
- Article first published online: 9 MAY 2006
- Manuscript Received: 1 MAR 2006
- CC activation;
Ever expanding: A RhI-catalyzed CC activation reaction of allenylcyclobutanes generates intermediate metallacycles that can be trapped with CO to produce a new [6+1] reaction. Functionalized monocyclic and bicyclic cycloheptenones are obtained in good-to-excellent yields with this [6+1] higher-order carbonylative cycloaddition reaction.