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Keywords:

  • allylation;
  • allylsilanes;
  • crotylation;
  • enantioselectivity;
  • ketones
Thumbnail image of graphical abstract

A strained allylsilane reagent is highly effective in the enantioselective allylation of hydroxyphenylketones. The method is uniquely tolerant both of sterically hindered aliphatic ketones and highly functionalized diaryl ketones and has been extended to include the first examples of highly diastereo- and enantioselective ketone crotylation, which provides access to both diastereomers.