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Thermoresponsive Micelles from Oligopeptide-Grafted Cyclotriphosphazenes


  • This work was supported by the SRC program of the Korea Science and Engineering Foundation through the Center for Intelligent Nano-Bio Materials at Ewha Womans University (Grant R11-2005-008-01002-0) and by a Korean Research Foundation Grant (KRF-2004-005-C00090).


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Hard graft: Amphiphilic cyclic phosphazene trimers grafted with hydrophobic oligopeptide (red) and hydrophilic methoxypolyethylene glycol (blue) show a variety of thermoresponsive properties including lower critical solution temperatures near body temperature. They form strong micelles in aqueous solution at an appropriate hydrophobic-to-hydrophilic balance.

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