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Keywords:

  • abyssomicin;
  • antibiotics;
  • atropisomerism;
  • natural products;
  • total synthesis
Thumbnail image of graphical abstract

Into the abyss: A total synthesis of abyssomicin C (1) through a metathesis-based strategy offers a highly convergent approach to the construction of analogues. A novel and potent atropisomer of the natural product 1 was thus discovered, namely atrop-abyssomicin C (2), which reveals subtle yet important structural differences to 1 (see structures; O red, C gray, H white).