This work was carried out as part of the EU COST action D27 “Prebiotic Chemistry and Early Evolution”, and was funded by the Engineering and Physical Sciences Research Council through the provision of a postdoctoral fellowship to C.A. and studentships to M.W.P. and M.A.C. We thank Dr. A. Parkes and Dr. M. Helliwell for preliminary experiments.
Direct Assembly of Nucleoside Precursors from Two- and Three-Carbon Units†
Article first published online: 17 AUG 2006
Copyright © 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 45, Issue 37, pages 6176–6179, September 18, 2006
How to Cite
Anastasi, C., Crowe, M. A., Powner, M. W. and Sutherland, J. D. (2006), Direct Assembly of Nucleoside Precursors from Two- and Three-Carbon Units. Angew. Chem. Int. Ed., 45: 6176–6179. doi: 10.1002/anie.200601267
- Issue published online: 11 SEP 2006
- Article first published online: 17 AUG 2006
- Manuscript Revised: 31 MAY 2006
- Manuscript Received: 31 MAR 2006
- EU COST action D27 “Prebiotic Chemistry and Early Evolution”
- Engineering and Physical Sciences Research Council
- prebiotic chemistry;
Sweetness and life: Pentose aminooxazolines—intermediates in potentially prebiotic nucleoside synthesis—can be produced in water from a reaction that bypasses the corresponding sugar. 2-Aminooxazole, a condensation product of glycolaldehyde and cyanamide, reacts with glyceraldehyde under mild conditions in a remarkable process that is essentially quantitative, and is highly stereoselective for ribose and arabinose aminooxazolines.