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New News about an Old Drug: Investigations on the Polymorphism of Triamcinolone Acetonide


  • This work was supported by the State of Schleswig-Holstein. We thank Prof. Dr. Wolfgang Bensch for allowing us to use his equipment and Dr. Michael Bolte, Institute of Inorganic Chemistry Frankfurt, for collecting the data of modification II.


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Even a very old drug holds some surprises when its polymorphism is investigated in detail. The commercially available form of triamcinolone acetonide (modification I) is a hydrate that contains a small amount of water, which is responsible for its stability. The removal of water results in a transformation into the previously unknown modification II. This finding may have a large impact on the production of the dosage form.