We thank the National Institute of General Medical Sciences for support (R01-GM-068649).
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Communication
Site-Selective Derivatization and Remodeling of Erythromycin A by Using Simple Peptide-Based Chiral Catalysts†
Article first published online: 21 JUL 2006
DOI: 10.1002/anie.200601490
Copyright © 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Lewis, C. A. and Miller, S. J. (2006), Site-Selective Derivatization and Remodeling of Erythromycin A by Using Simple Peptide-Based Chiral Catalysts. Angewandte Chemie International Edition, 45: 5616–5619. doi: 10.1002/anie.200601490
- †
Publication History
- Issue published online: 21 AUG 2006
- Article first published online: 21 JUL 2006
- Manuscript Revised: 12 JUN 2006
- Manuscript Received: 14 APR 2006
Keywords:
- asymmetric catalysis;
- erythromycin;
- nucleophiles;
- peptides;
- site-selectivity
Graphical Abstract
Reversal: Simple peptide-based nucleophilic catalysts can perturb the inherent reactivity hierarchy of the polyol natural product erythromycin A (see picture). Such catalyst-dependent modifications that reorganize natural product architecture may be of utility for generation of natural product analogs.