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Rh-Catalyzed Asymmetric Hydrogenation of α-Aryl Imino Esters: An Efficient Enantioselective Synthesis of Aryl Glycine Derivatives


  • This work was supported by the National Institutes of Health (GM58832).


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A highly enantioselective synthesis of aryl glycine derivatives from asymmetric hydrogenation was achieved by subjecting N-PMP-protected α-aryl imino esters to hydrogenation under Rh–bisphosphine catalysis (see scheme; PMP=para-methoxyphenyl, cod=cycloocta-1,5-diene). The PMP group could be easily removed for the preparation of enantiomerically pure aryl glycine derivatives.