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Short Synthesis of (+)-Cylindricine C by Using a Catalytic Asymmetric Michael Reaction with a Two-Center Organocatalyst

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  • This work was supported by RFTF, a Grant-in-Aid for the Encouragement of Young Scientists (A), and a Grant-in-Aid for Specially Promoted Research from the Japan Society for the Promotion of Science (JSPS) and the Ministry of Education, Culture, Sports, Science and Technology (MEXT).

Abstract

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Two for the price of one: The total synthesis of (+)-cylindricine C has been achieved in six steps using a catalytic asymmetric Michael reaction and tandem cyclization. A newly designed two-center organocatalyst gives good selectivity in this Michael reaction. TaDiAS=tartrate-derived diammonium salt.

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