We thank Professor Jerrold Meinwald and Dr. Ivan Keresztes, Cornell University, as well as Tim Peck and Dean Olson, Protasis-MRM, for helpful suggestions and discussions.
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Extending the Scope of NMR Spectroscopy with Microcoil Probes†
Article first published online: 22 SEP 2006
DOI: 10.1002/anie.200601789
Copyright © 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
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How to Cite
Schroeder, F. C. and Gronquist, M. (2006), Extending the Scope of NMR Spectroscopy with Microcoil Probes. Angew. Chem. Int. Ed., 45: 7122–7131. doi: 10.1002/anie.200601789
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Publication History
- Issue published online: 30 OCT 2006
- Article first published online: 22 SEP 2006
- Manuscript Received: 8 MAY 2006
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Keywords:
- analytical methods;
- capillary NMR spectroscopy;
- mass-sensitivity;
- NMR spectroscopy;
- structure elucidation
Abstract
Capillary NMR (CapNMR) spectroscopy has emerged as a major breakthrough for increasing the mass-sensitivity of NMR spectroscopic analysis and enabling the combination of NMR spectroscopy with other analytical techniques. Not only is the acquisition of high-sensitivity spectra getting easier but the quality of CapNMR spectra obtained in many small-molecule applications exceeds what can be accomplished with conventional designs. This Minireview discusses current CapNMR technology and its applications for the characterization of mass-limited, small-molecule and protein samples, the rapid screening of small-molecule or protein libraries, as well as hyphenated techniques that combine CapNMR with other analytical methods.