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Design and Implementation of a Highly Selective Minimal Self-Replicating System


  • We thank the University of St Andrews and the EPSRC for financial support. We are grateful to Caroline Horsburgh (mass spectrometry) and Melanja Smith (NMR spectroscopy) for technical assistance. We thank Prof G. von Kiedrowski for providing us with a copy of his SimFit program.


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Self-direction: A rationally designed self-complementary template (see picture) is capable of replication, thereby amplifying itself from a reaction mixture to the exclusion of its diastereomer. This approach allows a highly selective amplification by focusing on templates that display a high level of complementarity to transition states.