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Heterogeneous Asymmetric Catalysis with Homochiral Metal–Organic Frameworks: Network-Structure-Dependent Catalytic Activity


  • We acknowledge financial support from the NSF (CHE-0512495). W.L. is a Camille Dreyfus Teacher-Scholar. We thank Dr. Lin Zhang for experimental help.


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It's all in the preparation: Heterogeneous asymmetric catalysts based on two homochiral highly porous metal–organic frameworks formed from the same building blocks show remarkably different activity. Although both catalysts are based on twofold interpenetrated structures, one catalyzes the addition of diethylzinc to aromatic aldehydes with high enantioselectivity (up to 90 % ee), while the other is inactive.