Support by the DFG (Emmy Noether-Programm), the Fonds der Chemischen Industrie, Professor Paul Knochel, and the Ludwig-Maximilians-Universität is gratefully acknowledged. We thank Saltigo GmbH (Leverkusen) for the generous gift of chemicals.
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Communication
A Diaminochlorophosphine for Palladium-Catalyzed Arylations of Amines and Ketones†
Article first published online: 17 OCT 2006
DOI: 10.1002/anie.200602222
Copyright © 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Issue
Angewandte Chemie International Edition
Volume 45, Issue 45, pages 7627–7630, November 20, 2006
Additional Information
How to Cite
Ackermann, L., Spatz, J. H., Gschrei, C. J., Born, R. and Althammer, A. (2006), A Diaminochlorophosphine for Palladium-Catalyzed Arylations of Amines and Ketones. Angewandte Chemie International Edition, 45: 7627–7630. doi: 10.1002/anie.200602222
- †
Publication History
- Issue published online: 14 NOV 2006
- Article first published online: 17 OCT 2006
- Manuscript Revised: 25 JUL 2006
- Manuscript Received: 2 JUN 2006
Funded by
- DFG
- Fonds der Chemischen Industrie
Keywords:
- arylation;
- C
![[BOND]](http://onlinelibrarystatic.wiley.com/undisplayable_characters/00f8ff.gif)
N coupling; - cross-coupling;
- palladium;
- phosphane ligands
Graphical Abstract
Sterically hindered substituents on a secondary chlorophosphine 1 prevent formation of a diaminooxophosphine, and thereby allow for highly efficient arylation reactions of amines and α-C-H acidic ketones with (hetero)aryl chlorides.