This study was supported in part by Grants-in-Aid for Scientific Research and the “Academic Frontier” Project (2004–2009) from MEXT, Japan.
DNA Logic Gates Based on Structural Polymorphism of Telomere DNA Molecules Responding to Chemical Input Signals†
Article first published online: 10 OCT 2006
Copyright © 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 45, Issue 46, pages 7716–7719, November 27, 2006
How to Cite
Miyoshi, D., Inoue, M. and Sugimoto, N. (2006), DNA Logic Gates Based on Structural Polymorphism of Telomere DNA Molecules Responding to Chemical Input Signals. Angew. Chem. Int. Ed., 45: 7716–7719. doi: 10.1002/anie.200602404
- Issue published online: 20 NOV 2006
- Article first published online: 10 OCT 2006
- Manuscript Received: 15 JUN 2006
- Grants-in-Aid for Scientific Research
- “Academic Frontier” Project (2004–2009) from MEXT, Japan
- logic gates;
- molecular devices;
Environmentally sensitive: Structural polymorphism of telomere DNA molecules, which may be useful for the construction of molecular devices, is affected by environmental factors. Based on the conversion of the telomere DNA molecules among four states, simple and robust DNA logic gates that respond to two chemical input signals (M+ and H+) and generate a change in fluorescence intensity as the output signal were developed.