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Iridium-Catalyzed Enantioselective Synthesis of Allylic Alcohols: Silanolates as Hydroxide Equivalents


  • This research was supported by a Swiss National Science Foundation Grant and ETH Zürich. I.L. is grateful to the Roche Research Foundation and the Novartis Foundation for postdoctoral fellowships.


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Masked hydroxide: A highly regio- and enantioselective Ir-catalyzed allylic etherification of acyclic, achiral allylic carbonates can be achieved by using potassium silanolates as nucleophiles. The use of these hydroxide equivalents allows access to valuable chiral allylic alcohols.

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