Designed Fabrication of Multifunctional Magnetic Gold Nanoshells and Their Application to Magnetic Resonance Imaging and Photothermal Therapy

Authors

  • Jaeyun Kim,

    1. National Creative Research Initiative Center for Oxide Nanocrystalline Materials and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, Korea, Fax: (+82) 2-886-8457
    Search for more papers by this author
    • These authors contributed equally to this work.

  • Sungjin Park,

    1. Laboratory of Toxicology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul 151-744, Korea, Fax: (+82) 2-873-1268
    Search for more papers by this author
    • These authors contributed equally to this work.

  • Ji Eun Lee,

    1. National Creative Research Initiative Center for Oxide Nanocrystalline Materials and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, Korea, Fax: (+82) 2-886-8457
    Search for more papers by this author
  • Seung Min Jin Dr.,

    1. School of Chemistry, Seoul National University, Seoul 151-744, Korea
    2. Present address: Advanced Materials Division, Korea Research Institute of Chemical Technology, Daejeon 305-343, Korea
    Search for more papers by this author
  • Jung Hee Lee Prof. Dr.,

    1. Department of Radiology, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul 137-200, Korea
    Search for more papers by this author
  • In Su Lee Dr.,

    1. National Creative Research Initiative Center for Oxide Nanocrystalline Materials and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, Korea, Fax: (+82) 2-886-8457
    Search for more papers by this author
  • Ilseung Yang,

    1. School of Chemistry, Seoul National University, Seoul 151-744, Korea
    Search for more papers by this author
  • Jun-Sung Kim,

    1. Laboratory of Toxicology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul 151-744, Korea, Fax: (+82) 2-873-1268
    Search for more papers by this author
  • Seong Keun Kim Prof. Dr.,

    1. School of Chemistry, Seoul National University, Seoul 151-744, Korea
    Search for more papers by this author
  • Myung-Haing Cho Prof. Dr.,

    1. Laboratory of Toxicology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul 151-744, Korea, Fax: (+82) 2-873-1268
    Search for more papers by this author
  • Taeghwan Hyeon Prof. Dr.

    1. National Creative Research Initiative Center for Oxide Nanocrystalline Materials and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, Korea, Fax: (+82) 2-886-8457
    Search for more papers by this author

  • T.H. acknowledges financial support by the Korean Ministry of Science and Technology through the National Creative Research Initiative Program of the Korea Science and Engineering Foundation (KOSEF). M.H.C. is supported by the NSI-NCRC program of KOSEF. S.K.K. is supported by a National Research Laboratory Grant and a Chemical Genomics Grant. J.H.L. is supported by the Centre for Biological Modulators of the 21st Century Frontier R&D Program.

Abstract

original image

Targeting cancer: Multifunctional magnetic gold nanoshells (Mag-GNS) are prepared by coating silica spheres with gold nanoshells embedded with Fe3O4 nanoparticles. The Fe3O4 nanoparticles allow magnetic resonance imaging (MRI) for diagnosis, and the gold nanoshells enable photothermal therapy. By attaching an antibody to the Mag-GNS by a poly(ethylene glycol) (PEG) linker, cancer cells can be targeted.

Ancillary