These authors contributed equally to this work.
Designed Fabrication of Multifunctional Magnetic Gold Nanoshells and Their Application to Magnetic Resonance Imaging and Photothermal Therapy†
Article first published online: 30 OCT 2006
Copyright © 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 45, Issue 46, pages 7754–7758, November 27, 2006
How to Cite
Kim, J., Park, S., Lee, J. E., Jin, S. M., Lee, J. H., Lee, I. S., Yang, I., Kim, J.-S., Kim, S. K., Cho, M.-H. and Hyeon, T. (2006), Designed Fabrication of Multifunctional Magnetic Gold Nanoshells and Their Application to Magnetic Resonance Imaging and Photothermal Therapy. Angew. Chem. Int. Ed., 45: 7754–7758. doi: 10.1002/anie.200602471
T.H. acknowledges financial support by the Korean Ministry of Science and Technology through the National Creative Research Initiative Program of the Korea Science and Engineering Foundation (KOSEF). M.H.C. is supported by the NSI-NCRC program of KOSEF. S.K.K. is supported by a National Research Laboratory Grant and a Chemical Genomics Grant. J.H.L. is supported by the Centre for Biological Modulators of the 21st Century Frontier R&D Program.
- Issue published online: 20 NOV 2006
- Article first published online: 30 OCT 2006
- Manuscript Revised: 21 AUG 2006
- Manuscript Received: 20 JUN 2006
- Korean Ministry of Science and Technology
- National Creative Research Initiative Program of the Korea Science and Engineering Foundation (KOSEF)
- NSI-NCRC program of KOSEF
- National Research Laboratory
- Centre for Biological Modulators of the 21st Century Frontier R&D Program
- magnetic resonance imaging;
- photothermal therapy
Targeting cancer: Multifunctional magnetic gold nanoshells (Mag-GNS) are prepared by coating silica spheres with gold nanoshells embedded with Fe3O4 nanoparticles. The Fe3O4 nanoparticles allow magnetic resonance imaging (MRI) for diagnosis, and the gold nanoshells enable photothermal therapy. By attaching an antibody to the Mag-GNS by a poly(ethylene glycol) (PEG) linker, cancer cells can be targeted.