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Keywords:

  • asymmetric synthesis;
  • macrocycles;
  • macrolides;
  • metathesis;
  • total synthesis
Thumbnail image of graphical abstract

It works both ways: The convergent total synthesis of the oxopolyene macrolide RK-397 utilizes remote asymmetric induction and a two-directional chain synthesis to prepare the polyol portion of the molecule, as well as a cross-metathesis reaction of a trienal with a terminal alkene to append the polyene to the polyol.