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Keywords:

  • antibiotics;
  • hetero-Diels–Alder reaction;
  • macrocycles;
  • natural products;
  • total synthesis
Thumbnail image of graphical abstract

Beat the bugs: Total syntheses of the thiopeptide antibiotics GE2270A (X[BOND]Y=CH2[BOND]CH) and GE2270T (X[BOND]Y=CH[DOUBLE BOND]C) have been accomplished. The modular approach featured a hetero-Diels–Alder dimerization (A) to construct the trithiazolyl pyridine domain, and highly regioselective macrolactamizations (B) to furnish the macrocyclic core.