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Keywords:

  • antiproliferative agents;
  • cyclization;
  • natural products;
  • terpenoids;
  • total synthesis
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Structure assigned: The revised structure of (+)-hexacyclinol (1) proposed recently was confirmed following the total synthesis of the natural product. The synthesis was designed around the highly stereoselective Diels–Alder dimerization of an epoxyquinol monomer, followed by intramolecular acid-catalyzed cyclization.