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Keywords:

  • amination;
  • bismuth;
  • homogeneous catalysis;
  • nucleophilic substitution;
  • synthetic methods
Thumbnail image of graphical abstract

No preactivation of the alcohol substrates is required in allylic, propargylic, and benzylic aminations catalyzed by a combination of commercially available Bi(OTf)3 and KPF6, mostly at room temperature (see scheme). The substitution reactions of readily accessible allylic, propargylic, and benzylic alcohols with sulfonamides, carbamates, and carboxamides give the desired amine products in up to 99 % yield.