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The Crystallization Behavior of Proline and Its Role in Asymmetric Organocatalysis


  • I express my particular thanks to Dr. Bernard Kaptein of DSM Research for his kind help and many suggestions.


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What you have and what you get are not necessarily the same: for example, solid enantiomerically enriched proline provides solutions of constant ee, 99 % in CHCl3 and 50 % in DMSO. The Highlight discusses recent papers that give insight into the behavior of enantioenriched proline under heterogeneous conditions which may provide an explanation for the nonlinear effects sometimes observed.