Engineering the Structural Properties of DNA Block Copolymer Micelles by Molecular Recognition


  • This work, as part of the European Science Foundation EUROCORES Programme BIONICS, was supported by funds from the DFG and the EC Sixth Framework Programme. Additional funding was provided through the ERA-CHEMISRY programme and the DFG-Sonderforschungsbereich 625 “From Single Molecules to Nanostructured Materials”. The help of Dr. Roland Bauer for creating graphical representations is gratefully acknowledged.


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Transforming micelle structure: Amphiphilic DNA block copolymers form spherical micelles in solution. They can be transformed into rodlike micelles by hybridization with long DNA sequences, which consist of parallel aligned double-stranded DNA molecules “glued” together by hydrophobic interactions of the organic polymer (see picture). The template determines the length of the rodlike aggregates.