A Simple and Sensitive “Dipstick” Test in Serum Based on Lateral Flow Separation of Aptamer-Linked Nanostructures


  • This material is based upon work supported by the US Department of Energy (DE-FG02-01ER63179), the National Science Foundation through a Science and Technology Center of Advanced Materials for Purification of Water with Systems (WaterCAMPWS; CTS-0120978) and a Nanoscale Science and Engineering Center (NSEC; DMR-0117792) program, and by the US Army Research Laboratory and the US Army Research Office (DAAD19-03-1-0227).


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A quick plunge: By using lateral flow devices as a platform to separate aptamer-assembled nanoparticle (NP) aggregates, highly sensitive and selective colorimetric sensors were constructed that mimic litmus paper tests. Detection of cocaine in serum was also realized.