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Asymmetric Organocatalytic Domino Reactions


  • This work was supported by the Fonds der Chemischen Industrie (Kekulé Fellowship for C.G.) and the Deutsche Forschungsgemeinschaft (SPP 1179 Organocatalysis).


The current status of organic synthesis is hampered by costly protecting-group strategies and lengthy purification procedures after each synthetic step. To circumvent these problems, the synthetic potential of multicomponent domino reactions has been utilized for the efficient and stereoselective construction of complex molecules from simple precursors in a single process. In particular, domino reactions mediated by organocatalysts are in a way biomimetic, as this principle is used very efficiently in the biosynthesis of complex natural products starting from simple precursors. In this Minireview, we discuss the current development of this fast-growing field.