This work was supported by the EPSRC and AstraZeneca. The EPSRC Mass Spectrometry Service at the University of Wales, Swansea, is also thanked for their assistance.
A Second-Generation Catalyst for Intermolecular Hydroacylation of Alkenes and Alkynes Using β-S-Substituted Aldehydes: The Role of a Hemilabile P-O-P Ligand†
Article first published online: 17 OCT 2006
Copyright © 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 45, Issue 45, pages 7618–7622, November 20, 2006
How to Cite
Moxham, G. L., Randell-Sly, H. E., Brayshaw, S. K., Woodward, R. L., Weller, A. S. and Willis, M. C. (2006), A Second-Generation Catalyst for Intermolecular Hydroacylation of Alkenes and Alkynes Using β-S-Substituted Aldehydes: The Role of a Hemilabile P-O-P Ligand. Angew. Chem. Int. Ed., 45: 7618–7622. doi: 10.1002/anie.200603133
- Issue published online: 14 NOV 2006
- Article first published online: 17 OCT 2006
- Manuscript Received: 2 AUG 2006
- CH activation;
- hemilabile ligands;
- homogeneous catalysis;
- intermolecular hydroacylation;
Top of the P-O-Ps: Stabilization of a cationic rhodium catalyst with the hemilabile P-O-P ligand dpephos allows efficient intermolecular hydroacylation of challenging substrates (see scheme). Structural studies have established the role of the coordination of the oxygen atom, and a catalytically competent acyl–hydridorhodium intermediate was fully characterized.