Transition of Cationic Dipeptide Nanotubes into Vesicles and Oligonucleotide Delivery

Authors

  • Xuehai Yan,

    1. Beijing National Laboratory for Molecular Sciences (BNLMS), International Joint Laboratory, Key Laboratory of Colloid and Interface Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, P. R. China, Fax: (+86) 10-8261-2629
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  • Qiang He Dr.,

    1. Beijing National Laboratory for Molecular Sciences (BNLMS), International Joint Laboratory, Key Laboratory of Colloid and Interface Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, P. R. China, Fax: (+86) 10-8261-2629
    2. Max Planck Institute of Colloids and Interfaces, 14476 Golm/Potsdam, Germany
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  • Kewei Wang,

    1. Beijing National Laboratory for Molecular Sciences (BNLMS), International Joint Laboratory, Key Laboratory of Colloid and Interface Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, P. R. China, Fax: (+86) 10-8261-2629
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  • Li Duan,

    1. Beijing National Laboratory for Molecular Sciences (BNLMS), International Joint Laboratory, Key Laboratory of Colloid and Interface Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, P. R. China, Fax: (+86) 10-8261-2629
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  • Yue Cui Dr.,

    1. Beijing National Laboratory for Molecular Sciences (BNLMS), International Joint Laboratory, Key Laboratory of Colloid and Interface Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, P. R. China, Fax: (+86) 10-8261-2629
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  • Junbai Li Prof. Dr.

    1. Beijing National Laboratory for Molecular Sciences (BNLMS), International Joint Laboratory, Key Laboratory of Colloid and Interface Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, P. R. China, Fax: (+86) 10-8261-2629
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  • This work was supported financially by the National Natural Science Foundation of China (Nos. 20574077, 20471063, 20403022, and 90206035) and the Chinese Academy of Sciences, as well as the German Max Planck Society collaboration project. The authors acknowledge Hans Riegler for critical reading of the manuscript.

Abstract

original image

Password?—Vesicle! A cationic dipeptide can self-assemble into nanotubes at physiological pH values. Such self-assembled cationic dipeptide nanotubes (CDPNTs) are able to convert into vesicles spontaneously upon dispersion dilution and thus carry single-stranded DNA into HeLa cells across the biomembrane (see picture).

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