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Keywords:

  • asymmetric synthesis;
  • configuration determination;
  • halogen compounds;
  • polyethers;
  • terpenoids
Thumbnail image of graphical abstract

A victory for synthesis: The total synthesis of the marine triterpene polyether (+)-intricatetraol (1) has revealed its absolute configuration, which could not be determined even by spectroscopic methods. The approach features the enantioselective construction of the unique vicinal bromochloro functionality and an efficient olefin-metathesis strategy that takes the C2 symmetry of the target into consideration.