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Patterned Paper as a Platform for Inexpensive, Low-Volume, Portable Bioassays

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  • This research was supported by the National Institutes of Health (NIH) (GM065364). We used the Materials Research Science and Engineering Centers (MRSEC) shared facilities supported by the National Science Foundation (NSF) under award number DMR-0213805. This work also was supported by a predoctoral fellowship from NSF (A.W.M), a Damon Runyon Cancer Research Foundation Fellowship (DRG-1805-04) (S.T.P), and an Alexander and Margaret Stewart Trust Award and Massachusetts Technology Transfer Council Grant (M.J.B.).

Abstract

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By the book: A method for patterning paper with photoresist to create well-defined, millimeter-sized channels comprising hydrophilic paper bounded by hydrophobic polymer is described. This type of patterned paper is a prototype of a class of low-cost, portable, and technically simple platforms for running multiplexed bioassays with microliter volumes of a single biological sample.

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