Communication

Differential Analysis of 2D NMR Spectra: New Natural Products from a Pilot-Scale Fungal Extract Library†

  1. Frank C. Schroeder Dr.1,
  2. Donna M. Gibson Prof. Dr.2,
  3. Alice C. L. Churchill Dr.3,
  4. Punchapat Sojikul Dr.3,
  5. Eric J. Wursthorn5,
  6. Stuart B. Krasnoff Dr.4,
  7. Jon Clardy Prof. Dr.1

Article first published online: 20 DEC 2006

DOI: 10.1002/anie.200603821

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 46, Issue 6, pages 901–904, January 29, 2007

Additional Information

How to Cite

Schroeder, F., Gibson, D., Churchill, A., Sojikul, P., Wursthorn, E., Krasnoff, S. and Clardy, J. (2007), Differential Analysis of 2D NMR Spectra: New Natural Products from a Pilot-Scale Fungal Extract Library. Angewandte Chemie International Edition, 46: 901–904. doi: 10.1002/anie.200603821

Author Information

  1. 1

    Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA, Fax: (+1) 607-255-3407

  2. 2

    USDA-ARS-Plant Protection Research Unit, Ithaca, NY 14853, USA

  3. 3

    Boyce Thompson Institute for Plant Research, Ithaca, NY 14853, USA

  4. 4

    Department of Plant Pathology, Cornell University, Ithaca, NY 14853, USA

  5. 5

    Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA

  1. †

    This work was supported by a grant from the NIH (CA59021 to J.C.). F.C.S. and E.J.W. thank Jerrold Meinwald (Cornell University) and Matthew Gronquist (SUNY Fredonia) for their interest in the project and helpful discussions.

Publication History

  1. Issue published online: 22 JAN 2007
  2. Article first published online: 20 DEC 2006
  3. Manuscript Received: 18 SEP 2006

Funded by

  • NIH
  • CA59021

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article with Supporting Information (HTML) Get PDF (388K)

Keywords:

  • high-throughput screening;
  • metabolism;
  • natural products;
  • NMR spectroscopy;
  • structure elucidation

Graphical Abstract

Thumbnail image of graphical abstract

A 3D look at 2D spectra: Two previously unreported indole alkaloids could be rapidly identified from a library of unfractionated fungal extracts by using a newly developed protocol for the differential analysis of arrays of 2D NMR spectra (see picture). The technique thus represents an effective tool for the non-discriminatory characterization of secondary-metabolite mixtures.

View Full Article with Supporting Information (HTML) Get PDF (388K)