Strategies for the Synthesis of Fusicoccanes by Nazarov Reactions of Dolabelladienones: Total Synthesis of (+)-Fusicoauritone

Authors


  • We thank the National Institutes of Health [National Institute of General Medical Sciences (GM42897)] for support of this research. We also thank Dr. Josef Zapp (Saarland University) for providing us with NMR and MS spectra of authentic 1.

Abstract

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Attaining closure: A synthetic pathway leading to (+)-fusicoauritone (1) is highlighted by the use of a Julia condensation for preparation of an eleven-membered-dolabelladienone precursor for subsequent Nazarov cyclization to yield the 5-8-5 tricyclic diterpene skeleton.

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