We thank Dr. D. H. Huang and Dr. G. Siuzdak for assistance with NMR spectroscopy and mass spectrometry, respectively. We also gratefully acknowledge helpful discussions with Dr. P. G. Bulger and Dr. L. A. McAllister. Financial support for this work was provided by the National Institutes of Health (USA), the Skaggs Institute of Chemical Biology, and by Merck Sharp & Dohme (postdoctoral fellowship to D.J.E.).
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Communication
Total Synthesis of Platensimycin†
Article first published online: 29 SEP 2006
DOI: 10.1002/anie.200603892
Copyright © 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Nicolaou, K. C., Li, A. and Edmonds, D. J. (2006), Total Synthesis of Platensimycin. Angewandte Chemie International Edition, 45: 7086–7090. doi: 10.1002/anie.200603892
- †
Publication History
- Issue published online: 23 OCT 2006
- Article first published online: 29 SEP 2006
- Manuscript Received: 21 SEP 2006
Funded by
- National Institutes of Health (USA)
- Skaggs Institute of Chemical Biology
- Abstract
- Article
- References
- Cited By
Keywords:
- antibiotics;
- drug resistance;
- natural products;
- samarium diiodide;
- total synthesis
Graphical Abstract
Beat the superbugs: The newly discovered antibiotic platensimycin (1) promises to combat current drug-resistant infections. The natural product shows potent activity against Gram-positive bacteria and contains a novel molecular architecture. The total synthesis of this intriguing natural product that opens the way to a variety of otherwise inaccessible analogues has now been achieved (calculated structure shown on the right).