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Ultrafine Hydrogel Nanoparticles: Synthetic Approach and Therapeutic Application in Living Cells


  • We thank Dr. Kei Sun for the help with TEM images. This work was supported by National Cancer Institute UIP contract N01-CO-37123.


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Licensed to kill: A method for obtaining ultrafine hydrophilic polyacrylamide-based nanoparticles that encapsulate meta-tetra(hydroxyphenyl)chlorin (mTHPC) has been developed. Rat C6 glioma cells exposed to infrared light were killed (red) in the presence of the mTHPC-encapsulating nanoparticles while the cells without exposure to light were still alive (green).

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