Gold- and Indium-Catalyzed Synthesis of 3- and 6-Sulfonylindoles from ortho-Alkynyl-N-sulfonylanilines

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Abstract

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Consecutive formation of C[BOND]N and C[BOND]S bonds: The gold-catalyzed intramolecular aminosulfonylation of 2-alkynyl-N-sulfonylanilines 1 (R1=H) produces 3-sulfonylindoles 2 in good to high yields, whereas the indium-catalyzed aminosulfonylation of 2-alkynyl-6-methoxy-N-sulfonylanilines 1 (R1=MeO) affords 6-sulfonylindoles 3 as the major products (see scheme).

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