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Keywords:

  • β-amyloids;
  • Alzheimer's disease;
  • amyloid fibrils;
  • protein design;
  • self-assembly
Thumbnail image of graphical abstract

Le fabuleux destin d'amyloid disease: A peptide-derived inhibitor for amyloid diseases binds the Alzheimer's disease β-amyloid peptide (Aβ40) and the type II diabetes islet amyloid polypeptide (IAPP) and blocks cytotoxic self-assembly of both peptides. Evidence is also presented for a high-affinity interaction between Aβ40 and IAPP that results in cross-suppression of cytotoxic self-association of both peptides.