Communication

IAPP Mimic Blocks Aβ Cytotoxic Self-Assembly: Cross-Suppression of Amyloid Toxicity of Aβ and IAPP Suggests a Molecular Link between Alzheimer's Disease and Type II Diabetes†

  1. Li-Mei Yan Dipl.-Chem.,
  2. Aleksandra Velkova Dipl.-Ing.,
  3. Marianna Tatarek-Nossol Dipl.-Chem.,
  4. Erika Andreetto Dipl.-Chem.,
  5. Aphrodite Kapurniotu Prof. Dr.

Article first published online: 4 JAN 2007

DOI: 10.1002/anie.200604056

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 46, Issue 8, pages 1246–1252, February 12, 2007

Additional Information

How to Cite

Yan, L.-M., Velkova, A., Tatarek-Nossol, M., Andreetto, E. and Kapurniotu, A. (2007), IAPP Mimic Blocks Aβ Cytotoxic Self-Assembly: Cross-Suppression of Amyloid Toxicity of Aβ and IAPP Suggests a Molecular Link between Alzheimer's Disease and Type II Diabetes. Angew. Chem. Int. Ed., 46: 1246–1252. doi: 10.1002/anie.200604056

Author Information

  1. Laboratory of Bioorganic and Medicinal Chemistry, Institute of Biochemistry, University Hospital of the RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany, Fax: (+49) 241-8082427 http://www.ukaachen.de/content/person/4605521

  1. †

    We are grateful to J. Bernhagen for helpful discussions and to K. Alexandrov and R. S. Goody for help with analysis of fluorescence data. We thank A. Kazantzis, K. Tenidis, M. Waldner, H. Vasen, and M. Müsken for peptide synthesis and D. Bächle, PANATecs GmbH, R. Fischer, and H. Kalbacher for MALDI measurements. This work was supported in part by the Deutsche Forschungsgemeinschaft (DFG). Aβ=β-amyloid peptide; IAPP=islet amyloid polypeptide.

Publication History

  1. Issue published online: 5 FEB 2007
  2. Article first published online: 4 JAN 2007
  3. Manuscript Received: 3 OCT 2006

Funded by

  • Deutsche Forschungsgemeinschaft

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