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Keywords:

  • aldol reaction;
  • amino alcohols;
  • biocatalysis;
  • lyases;
  • threonine aldolase
Thumbnail image of graphical abstract

Dynamic and successful: The asymmetric synthesis of 2-amino-1-phenylethanol was achieved by aminomethylation of benzaldehyde in the presence of the two enzymes L-threonine aldolase and L-tyrosine decarboxylase in a novel one-pot, two-enzyme process (see scheme). A modified method with three enzymes led to the enantioenriched amino alcohol in very high yield.