Accelerating Reactions with Microreactors at Elevated Temperatures and Pressures: Profiling Aminocarbonylation Reactions


  • S.L.B. thanks the National Institutes of Health (GM46059) for funding and is also indebted to Merck, Amgen, and Boehringer-Ingelheim for unrestricted support. K.F.J. thanks the MicroChemical Systems Technology Center for funding. We are also grateful to Engelhard for a generous donation of palladium acetate.


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Squeeze play: Pressurized microreactor systems greatly expand the range of reaction conditions and accelerate gas–liquid mass transfer. Heck aminocarbonylation reactions (see scheme) exemplify the potential for the quick and safe scanning of reagents and reaction conditions. The yield of amide increases with an increase in temperature and the selectivity for α-ketoamide production (n=2) increases at lower temperature and higher pressure.