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A Synthetic Supramolecular Construct Modulating Protein Assembly in Cells


  • This work was supported by the Sofja Kovalevskaja Award of the Alexander von Humboldt Foundation to L.B. The authors would like to thank Dr. Carsten Schultz, Alen Piljic, and Robin Vetter for their help with fluorescence microscopy and discussions, and Dr. Kirill Alexandrov and Christine Nowak for their help with protein expression and purification.


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Supramolecular chemistry in the cell: Synthetic supramolecular constructs ligated to proteins modulate protein assembly (see picture). The interaction between the supramolecular elements is operative both in vitro and in cells, and drives the proteins to assemble, as revealed by a strong FRET effect between the engineered proteins.