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Kinetic Recognition of AT-Rich DNA by Ruthenium Complexes

Authors

  • Pär Nordell,

    1. Department of Chemical and Biological Engineering/Physical Chemistry, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden, Fax: (+46) 31-772-3858
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  • Fredrik Westerlund Dr.,

    1. Department of Chemical and Biological Engineering/Physical Chemistry, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden, Fax: (+46) 31-772-3858
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  • L. Marcus Wilhelmsson Dr.,

    1. Department of Chemical and Biological Engineering/Physical Chemistry, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden, Fax: (+46) 31-772-3858
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  • Bengt Nordén Prof.,

    1. Department of Chemical and Biological Engineering/Physical Chemistry, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden, Fax: (+46) 31-772-3858
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  • Per Lincoln Dr.

    1. Department of Chemical and Biological Engineering/Physical Chemistry, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden, Fax: (+46) 31-772-3858
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  • This work was supported by grants from the Swedish Research Council (VR).

Abstract

original image

Finding AT tracts: High selectivity for long AT sequences can be attained through kinetically controlled DNA threading intercalation by binuclear ruthenium(II) complexes (see picture). The rate of intercalation is strongly correlated to the number of consecutive AT base pairs and is up to 2500-times higher with poly(dAdT)2 than with mixed-sequence DNA.

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