Raftlike Polyvalent Inhibitors of the Anthrax Toxin: Modulating Inhibitory Potency by Formation of Lipid Microdomains


  • We acknowledge support from the NIH (U01 AI056546) and NSF (CTS-0608978).


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The good fat: Anthrax toxin inhibitors that contain lipid microdomains have been synthesized. The clustering of inhibitory peptides in membrane microdomains results in a significant increase in inhibitory potency. Peptide clustering and microdomain formation can be actively modulated in response to an external stimulus.