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Keywords:

  • aldehydes;
  • asymmetry;
  • domino reactions;
  • multicomponent reactions;
  • organocatalysis
Thumbnail image of graphical abstract

As easy as pouring! Three C[BOND]C bonds, up to three stereocenters, and ee values greater than 97 % are created in a new organocatalyzed multicomponent domino reaction (see picture; TMS=trimethylsilyl; EWG=electron-withdrawing group). Very high enantioselectivity, control of the substituents, easy handling, and user-friendly reaction conditions are key features of this transformation.