This work was made possible by a grant from the Danish National Research Foundation. Thanks are expressed to Dr. Jacob Overgaard for performing X-ray analysis.
A New Approach for an Organocatalytic Multicomponent Domino Asymmetric Reaction†
Article first published online: 29 DEC 2006
Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 46, Issue 7, pages 1101–1104, February 5, 2007
How to Cite
Carlone, A., Cabrera, S., Marigo, M. and Jørgensen, K. (2007), A New Approach for an Organocatalytic Multicomponent Domino Asymmetric Reaction. Angew. Chem. Int. Ed., 46: 1101–1104. doi: 10.1002/anie.200604479
- Issue published online: 29 JAN 2007
- Article first published online: 29 DEC 2006
- Manuscript Received: 1 NOV 2006
- Danish National Research Foundation
- domino reactions;
- multicomponent reactions;
As easy as pouring! Three CC bonds, up to three stereocenters, and ee values greater than 97 % are created in a new organocatalyzed multicomponent domino reaction (see picture; TMS=trimethylsilyl; EWG=electron-withdrawing group). Very high enantioselectivity, control of the substituents, easy handling, and user-friendly reaction conditions are key features of this transformation.